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首頁(yè) /診斷試劑 /腫瘤標(biāo)準(zhǔn)品 /Mutation /AI-Edigene? ERBB2 p.A775_G776insYVMA Reference Standard Plus

AI-Edigene? ERBB2 p.A775_G776insYVMA Reference Standard Plus

CBP10416

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Introduction 
Format Genomic DNA
Description ERBB2 (HER2) A775_G776insYVMA results in the insertion of four amino acids in the protein kinase domain of the Erbb2 (Her2) protein between amino acids 775 and 776 (UniProt.org). A775_G776insYVMA results in the same amino acid change as M774_A775insAYVM, which leads to constitutive phosphorylation of Erbb2 (Her2) and is transforming in cell culture (PMID: 17311002, PMID: 29967253).
   
Technical Data 
DNA Change c.2324_2325ins12 ATACGTGATGGC
AA Change p.A775_G776insYVMA
Mutation type Insertion - In frame
Zygosity Homozygous
Allelic Frequency 100%
Transcript ENST00000269571
Cosmic ID COSM20959
Chr position(GRCh37) chr17:37880995_37880996
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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